This meme comes from the series name “f.r.i.e.n.d.s” which is an American comedy.
Because of the expanding of ancient Roman established “Constantinople” or “New Rome”that becomes a capital city.
The phrase “eis ten polin” becomes a title for the city “Istanpolin” Through a progression of changes over a range of hundred of years, this name became “Istanbul” in 1930.
It the meme of teaching someone to speak by repeating the sentence but at last it would be the thing that people familiar with or not saying it correctly.
As in this meme, they want to tell that Istanbul is the name that people are calling on now not Constantinople.